Week one for the NFL season always brings about the unexpected, and this year was no different.

Injuries are the other harsh truth of the first week, and chances are a lot of you are hurting. There are plenty of players that go undrafted that you can pick up for a big boost, and here are my top three pickups going into this weekend.

1. Brandon Jackson, RB Green Bay

Chances are, if you’re reading this and haven’t picked up Jackson already, then it’s probably too late. On the off-chance that you’re in the one league where everyone has dial-up Internet and Jackson is still available, you’d be doing yourself a big disservice by passing him up.

With Ryan Grant out for the season and John Kuhn as the only other member of the backfield, Jackson is going to be seeing a lot of action for a long time.

Green Bay still has one of the most high-powered offenses in the league, and the feature back in a high-powered offense is always a safe play.

2. Michael Vick, QB Philadelphia

Nobody had a bigger coming out party in week one than the greatest scrambling quarterback of all time. Vick showed fantasy players last week what video game players have known since Madden 2004: Michael Vick has the potential to be the most electrifying, dominating player in the NFL. With the weapons he has around him in Philly, Vick is immediately elevated to a top-10 level quarterback when starting.

Now that Kevin Kolb is out after suffering a concussion in week one, this is Vick’s offense, at least for the time being. For anybody who needs semi-long term help at QB, Vick should be your top priority.

3. Seneca Wallace, QB Cleveland

There’s no indicator that Wallace will be starting under center, as Cleveland has called starting quarterback Jake Delhomme a game time decision, but here’s the thing: If you’re a Kolb/Matt Stafford starter who is lost on what to do for this week, Wallace may be a good pickup.

The Browns have the Chiefs at home, and I’m not sure that the brass in Cleveland has confidence in Delhomme as a long-term starter. Mike Holmgren snatched Wallace up from Seattle, Holmgren’s former team, to have a quarterback he’s familiar with.

If nothing else, it’s looking like Wallace will play this week against Kansas City.