Cee-Lo and Danger Mouse must know something about music everyone else must have missed.

The singer and producer who make up the duo Gnarls Barkley have managed to open ears and spin heads once again, this time with their brilliant sophomore album “The Odd Couple.”

In “Going On,” Danger Mouse reels us in with some fresh guitar play, then takes us on a journey of perfectly orchestrated organ and percussion, as the poetic and mesmerizing Cee-Lo does what he does best.

“Anyone that needs what they want and doesn’t want what they need / I want nothing to do with,” Cee-Lo says, “And to do what I want and to do what I please / is first on my to-do list.”

As far as the overall production goes, the diabolical genius Danger Mouse maintains a consistent vintage-like atmosphere, giving off a strong ’50s and ’60s surfer vibe. Something so odd working so effectively only solidifies Gnarls Barkley’s position as one of the freshest acts in music today.

In “Blind Mary,” a sweet, heartfelt tribute to a woman who can’t see, Cee-Lo sings: “She’s my friend, she doesn’t judge me / She has no idea I’m ugly / So I’ve absolutely nothing to hide / Because I’m so much prettier inside.”

These are not your average songs about love and love lost. From the menacing “Surprise” to the suspenseful “Neighbors,” the team hits us over the head repeatedly, letting us know that music is as flexible as life and knows no boundaries.

The only piece that may not be too attractive is “Open Book,” which seems to be a bit too messy and experimental. With its wild drum pattern placed over jungle sounds, it lacks a clear, likeable rhythm. But perhaps that was the intention.

The majority of the tracks are barely over three minutes long. Each song is concise and engaging.

When Gnarls Barkley’s debut album “St. Elsewhere” dropped, it was almost as if Cee-Lo and Danger Mouse had come in from another planet. It’s been two long years since then and, like “St. Elsewhere,” “The Odd Couple” sets itself far apart from today’s popular music.

Now, the world’s greatest and funkiest weirdos have finally returned to Earth. Once again, they should be welcomed with open arms and ears.